Initial starting dose of inhaled corticosteroids in adults with asthma: a systematic review

Initial starting dose of inhaled corticosteroids in adults with asthma: a systematic review.

BACKGROUND Asthma guidelines vary in their recommendations for the initial dose of inhaled corticosteroid (ICS) in asthma. A systematic review of the literature was conducted to establish the optimal starting dose of ICS for asthma in adults. METHODS Randomised controlled trials comparing two doses of the same ICS in adults with asthma and no concomitant inhaled or oral corticosteroid were as...

Dose response of inhaled corticosteroids in children with persistent asthma: a systematic review.

OBJECTIVE To assess the dose-response relationship (benefits and harms) of inhaled corticosteroids (ICSs) in children with persistent asthma. METHODS We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared ≥2 doses of ICSs in children aged 3 to 18 years with persistent asthma. Medline was searched for articles published between 1950 and August 2...

Starting with a higher dose of inhaled corticosteroids in primary care asthma treatment.

New British guidelines on the treatment of asthma (9) advocate starting with a higher dose of inhaled corticosteroids in newly detected asthma patients. We investigated whether initiating inhaled steroid treatment with a higher dose is clinically more effective than a lower dose in steroid naive patients with asthma. The study had a 13-wk randomized, double-blind, parallel design: 1-mo treatmen...

Review: adults who require inhaled corticosteroids benefit from a moderate starting dose.

Inhaled corticosteroids and long term outcome in adults with asthma.

The concept that treatment with inhaled corticosteroids (ICS) may improve long term lung function by reversing or minimising the effects of airway remodelling remains an attractive one but, until now, unproven. It is therefore with much interest that we read the publications of two observational studies by Lange et al and by Dijkstra et al. Both groups of authors hypothesised that asthmatic ind...